CEP 41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA ‐dependent deciliation
نویسندگان
چکیده
منابع مشابه
Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity
How microtubule-associated motor proteins are regulated is not well understood. A potential mechanism for spatial regulation of motor proteins is provided by posttranslational modifications of tubulin subunits that form patterns on microtubules. Glutamylation is a conserved tubulin modification [1] that is enriched in axonemes. The enzymes responsible for this posttranslational modification, gl...
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Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation, and glutamylation are abundant. These modifications exhibit stereotyped patterns suggesting spatial and temporal control of microtubule functions. Using human-engineered and differentially modified microtubules we fin...
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Cilia are protrusions on the surface of cells. They are frequently motile and function to propel cells in an aqueous environment or to generate fluid flow. Equally important is the role of immotile cilia in detecting environmental changes or in sensing extracellular signals. The structure of cilia is supported by microtubules, and their formation requires microtubule-dependent motors, kinesins,...
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Membranes from the gill cilia of the mollusc Aequipecten irradians may be solubilized readily with Nonidet P-40. When the detergent is removed from the solution by adsorption to polystyrene beads, the proteins of the extract remain soluble. However, when the solution is frozen and thawed, nearly all of the proteins reassociate to form membrane vesicles, recruiting lipids from the medium. The me...
متن کاملEffects of deciliation of tubulin messenger RNA activity in sea urchin embryos.
Sea urchin embryos contain a large cytoplasmic pool of microtubular protein, from which they can regenerate cilia several times without the need for synthesizing additional tubulin. The present studies were initiated to determine if a requirement for new tubulin synthesis can be induced by depleting this pool through repeated cycles of deciliation. By the third round of deciliation, there is a ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2019
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201948290